Author: Claudia Bernardini, Luis Falcato, Nathalie Scherz, Philip Bruggmann

Theme: Clinical Research Year: 2019

Background: Treating people who inject drugs (PWID) is crucial to achieve the WHO goal of hepatitis
C (HCV) elimination. After successful treatment, this population remains at risk for re-infection. We
show real life data about re-infection incidence after HCV treatment with DAAs in an integrated care
setting of a low-threshold opioid agonist treatment (OAT) in Switzerland, where – beside full range of
medical and social care –prevention-measures like sterile injection paraphernalia dispensation and
peer-education are provided.
Methods:All patients with a diagnosis of opioid or stimulant use disorder and an observational
period of a minimum of 24 weeks after SVR following HCV DAA treatment have been included in this
retrospective analysis. Results of HCV RNA tests after SVR and the time-period of re-infection
surveillance have been assessed during July 2014 und January 2018.
Results:57 patients were included (77% male, mean age: 48 years). 97% were in OAT, 2% had a
stimulant use disorder. Additional substance use disorders (cocaine: 46%, alcohol: 40%), and
advanced liver disease (25%) were prevalent. Lifetime injection drug use has been reported for 24
patients (42%). In total follow-up period of 98.88 years (min. 0.51, max. 3.43, median: 1.66) 1 HCV reinfection occurred resulting in 1 re-infection per 100 person-years.
Conclusion: HCV re-infection after DAA treatment in an integrated care setting also offering
prevention measures was rare. HCV follow-up care for PWID in an all-under-one-roof setting has the
potential to prevent re-infection and therefore contribute significantly to the WHO goal of HCV
Disclosure of Interest Statement PB has served as advisor and speaker for, and has received project,
travel and research grants from Merck, AbbVie, Gilead and Mundipharma. CB has received travel
grants from Abbvie and Gilead. LF and NS have no conflicts of interest to declare.

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